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KMID : 0366919930050010001
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Sungkyun Pharmceutical Journal
1993 Volume.5 No. 1 p.1 ~ p.6
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The Changes of Methylated Amino Acid Contents in Serum of the Diabetic Rats
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Lee Hyang-Woo
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Abstract
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In order to investigate the relationship between methylated amino acids and diabetes, we investigated the changes of serum concentration of methylated amino acids in serum of the experimentally induced diabetic rats. The diabetic symptom was induced by injectly alloxan 100 mg/kg intraperitoneally. The serum content of N^G-monomethylarginine(MMA), N^G, N^G-dimethyl-arginine(DMA) and N^G, N^G-dimethylarginine(D´MA) were analyzed by HPLC. The results are as followings ① There was no change in serum content of MMA in the diabetic group. ② But it was observed that the amounts of DMA and D´MA were increased remarkably in the diabetic group. Specifically, D´MA content was increased about 7 times in comparision to that of the control group. ③ However, the concentration of trimethyllysine in RBC was decreased slightly in diabetic group but not significant statistically.
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KEYWORD
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